ANGPTL5蛋白產(chǎn)品信息
產(chǎn)品名稱：重組人 ANGPTL5 蛋白|Angiopoietin-related Protein 5 ( ANGPTL5 ) Protein|廠家現(xiàn)貨|價格
表達方式: A DNA sequence encoding the mature form of human ANGPTL5 (NP_835228.2) (Asn 26-Lys 388) was fused with the GST tag at the N-terminus.
種屬: Human
表達宿主: Insect cells

ANGPTL5蛋白質控指標
純度: > 90 % as determined by SDS-PAGE.
內(nèi)**: < 1.0 EU per 1μg of the protein as determined by the LAL method.
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Met
分子量: The recombinant human ANGPTL5/GST chimera consists of 588 amino acids and predicts a molecular mass of 68 kDa as estimated in SDS-PAGE under reducing conditions.
緩沖液: 
Lyophilized from sterile 50mM Tris, 100mM Nacl, pH 8,  0.5mM GSH,  0.5mM PMSF,  0.5mM EDTA

ANGPTL5蛋白使用指南
儲存方法: Store it under sterile conditions at -70℃ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ANGPTL5蛋白背景綜述
Angiopoietin-related protein 5, also known as, Angiopoietin-like 5 and ANGPTL5, is a member of the Angiopoietin family. Angiopoietin family consists of ANGPT1, ANGPT2, ANGPT4, ANGPTL1 (ANGPT3), ANGPTL2, ANGPTL3 (ANGPT5), ANGPTL4, ANGPTL5, ANGPTL6 and ANGPTL7. They are secreted proteins possessing an amino-terminal coiled-coil domain and a carboxyl-terminal fibrinogen-like domain and are known as angiogenic factors. They act as growth factors that promote angiogenesis, the formation of blood vessels from pre-existing blood vessels. Like other members of the angiopoietin family, ANGPTL5 protein also has an N-terminal cleavable signal peptide, a predicted coiled-coil domain, and a fibrinogen-like domain. ANGPTL5 is mainly expressed in ***** human heart. Loss of function mutations of ANGPTL3, ANGPTL4, and ANGPTL5 are associated with a low triglyceride concentration. They are regulators of lipoprotein metabolism in humans. Inhibition of these ANGPTLs will be useful for dyslipidemia to prevent cardiovascular disease.
參考文獻
1. Zeng, L. et al., 2003, J Hum Genet. 48 (3): 159-62.
2. Katoh, Y. et al., 2006, Int J Mol Med. 17 (6): 1145-9.
3. Niki, D. et al., 2009, Dev Growth Differ. 51 (9): 821-32.
4. Miida, T. et al., 2009, Curr Opin Lipidol.

包裝：20ug

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