Interleukin 8 / IL8蛋白產(chǎn)品信息
產(chǎn)品名稱：重組食蟹猴 Interleukin 8 / IL8 蛋白|Interleukin 8 Protein|產(chǎn)品詳情|價格
別名: IL8, CXCL8
表達(dá)方式: A DNA sequence encoding the cyno IL8 (P67814)(Ala23-Pro101) was expressed and purified  with an initial Met.
種屬: Cynomolgus
表達(dá)宿主: E.coli

Interleukin 8 / IL8 Protein QC Testing
純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: Please contact us for more information.
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Met
分子量: 
The recombinant cyno IL8 consists of 80 amino acids and has a calculated molecular mass of 9.3 KDa. It migrates as an 9 KDa band in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile 50mM  Tris, 250mM NaCl, pH 7.5.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
Interleukin 8 / IL8 Protein Usage Guide
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Interleukin 8 / IL8蛋白背景綜述
Interleukin 8, also known as IL8, is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL8 in their storage vesicles.IL8 is secreted and is an important mediator of the immune reaction in the innate immune system response. Interleukin 8 has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. Interleukin 8 also induces phagocytosis once they have arrived. Interleukin 8 is also known to be a potent promoter of angiogenesis. In target cells, IL8 induces a series of physiological responses required for migration and phagocytosis, such as increase of intracellular Ca2+, exocytosis (e.g. histamine release), and respiratory burst. Interleukin 8 is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. Interleukin 8 is often associated with inflammation. High levels of IL8 have been shown to reduce the likelihood of positive responses to antipsychotic medication in schizophrenia.
參考文獻(xiàn)
Modi WS. et al., 1990, Hum Genet. 84 (2): 185-7.
Utgaard JO. et al., 1998, J Exp Med. 188 (9): 1751-6.
Wolff B. et al., 1998, J Exp Med. 188 (9): 1757-62.

包裝：20ug

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