Cynomolgus CXCL12 / SDF-1蛋白產(chǎn)品信息

產(chǎn)品名稱：重組食蟹猴 CXCL12 / SDF-1 蛋白|Cynomolgus Stromal Cell-Derived Factor 1 Protein| 現(xiàn)貨
別名: CXCL12
表達(dá)方式: A DNA sequence encoding the Cynomolgus ( Macaca fascicularis ) CXCL12 ( NP_001036851.1 ) ( Met 1 - Lys 89 ) was fused with the Fc region of human IgG1 at the C-terminus
種屬: Cynomolgus
表達(dá)宿主: Human Cells

Cynomolgus CXCL12 / SDF-1蛋白質(zhì)控指標(biāo)

純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Lys 23
分子量: The recombinant cynomolgus CXCL12 / Fc is a disulfide-linked homodimer The reduced monomer consists of 309 amino acids and has a calculated molecular mass of 34.8 kDa. The apparent molecular mass of the reduced cynomolgus CXCL12 / Fc monomer is approximately 39 kDa in SDS-PAGE under reducing conditions due to glycosylation
緩沖液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

Cynomolgus CXCL12 / SDF-1蛋白使用指南
儲(chǔ)存方法:  Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:  A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Cynomolgus CXCL12 / SDF-1蛋白背景綜述
Cynomolgus stromal cell-derived factor 1, also known as C-X-C motif chemokine 12, Intercrine reduced in hepatomas, Pre-B cell growth-stimulating factor, SDF-1, PBSF, CXCL12 and SDF1, is a secreted protein which belongs to the intercrine alpha (chemokine CxC) family. CXCL12 / SDF-1 is widely expressed in various organs including heart, liver, brain, kidney, skeletal muscle, and lymphoid organs, and is highly conserved between species. CXCL12 / SDF-1 is expressed in two isoforms from a single gene that encodes two splice variants, SDF1α and SDF1β, which are identical except for the four residues present in the C-terminus of SDF1β but absent from SDF1α. As a highly efficacious lymphocyte chemoattractant, CXCL12 / SDF-1 activates and directs the migration of leukocytes in response to proinflammatory stimuli such as LPS, TNF, or interleukins. It has been demonstrated that CXCL12 / SDF-1 promotes tumor growth and malignancy, enhances tumor angiogenesis, participates in tumor metastasis, and thus plays an important role in carcinoma pathogenesis. In addition, CXCL12 / SDF-1 is identified as the biological ligand for CXC-chemokine receptor 4 (CXCR4), which is widely expressed in leukocytes and acts as the cofactor for HIV-1 entry, and inhibits the HIV-1 infection. Furthermore, SDF1 is rapidly inactivated via N-terminal processing by cathepsin G associated with the membrane of B-cells, NK cells and to a lesser extent, T-cells.
參考文獻(xiàn)
Bleul, C.C. et al., 1996, Nature. 382: 829-833.
Sapede, D. et al., 2005, Proc. Natl. Acad. Sci. USA. 102: 1714-1718.
Delgado, M.B. et al., 2001, Eur. J. Immunol. 31: 699-707.
Orimo, A. et al., 2005, Cell. 121: 335-348.
Kryczek, I. et al., 2007, Am. J. Physiol. Cell. Physiol. 292: C987-995.
Bbalabanian, K. et al., 2005, J. Biol. Chem. 280: 35760-35766.

包裝：10ug

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