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C-C motif ligand 6 / CCL6蛋白產(chǎn)品信息
產(chǎn)品名稱：重組小鼠 CCL6 / C-C motif ligand 6 蛋白|C-C motif ligand 6 / CCL6 Protein|技術(shù)資料|現(xiàn)貨
別名: RP23-320E6.4, MRP-1, Scya6, c10
表達方式: A DNA sequence encoding the mouse CCL6 ( P27784 ) ( Met 1 - Ala 116 ) was fused with a polyhistidine tag at the C-terminus
種屬: Mouse
表達宿主: Human Cells

C-C motif ligand 6 / CCL6蛋白質(zhì)控指標
純度: > 90 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Gly 22
分子量: The recombinant mouse CCL6 consists of 106 amino acids and has a predicted molecular mass of 12 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmCCL6 is approximately 14 kDa
緩沖液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

C-C motif ligand 6 / CCL6蛋白使用指南
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

C-C motif ligand 6 / CCL6蛋白背景綜述
Chemokine (C-C motif) ligand 6 (CCL6) also known as C-C chemokine C10 is a small cytokine belonging to the chemokine CC family that has only been identified in rodents. C10 is a recently described member of the beta-chemokine subfamily of the chemokine superfamily of cytokine proteins. In contrast to this genomic structure, the C10 gene has four exons, with a novel second exon of 48 nucleotides. Exons 3 and 4 of C10 contain four cysteines distributed in the same manner as in exons 2 and 3 of other beta-chemokine family members. C10 is involved in the chronic stages of host defense reactions. In vitro evidence, C10 significantly enhanced the bacterial phagocytic activity of peritoneal macrophages. In addition, in vivo evidence suggested that C10 therapy significantly reduced the amount of material that leaked from the damaged gut. The C10 chemokine rapidly promotes disease resolution in the cecal ligation and puncture (CLP) model through its direct effects on the cellular events critically involved in host defense during septic peritonitis. CCL6 may be a mediator released by microglia for cell-cell communication under physiological as well as pathological conditions of CNS. CCL6 can be either a positive or negative target for Myc oncoproteins, thus it may alter tumor behavior by relieving its growth factor dependency and by promoting invasiveness as a result of local tissue apoptosis.
參考文獻
Steinhauser ML, et al., 2000, Infect Immun. 68(11):108-14.
Berger MS, et al., 1993, DNA Cell Biol. 12(9): 839-47.
Kanno M, et al., 2005, J Neuroimmunol. 167(1-2): 72-80.
Yi F, et al., 2003, Cancer Res. 63(11): 2923-32.

包裝：10ug

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查詢關(guān)鍵詞：重組小鼠 CCL6 / C-C motif ligand 6 蛋白,C-C motif ligand 6 / CCL6 Protein,技術(shù)資料,現(xiàn)貨，原料藥，大包裝定制，現(xiàn)貨促銷，醫(yī)藥中間體，科學儀器，實驗室耗材，生化試劑，創(chuàng)賽中國,細胞因子
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