CXCL2 / GRO2蛋白產(chǎn)品信息

產(chǎn)品名稱：重組小鼠 CXCL2 / GRO2 / MIP-2 蛋白|Mouse CXCL2 / GRO2 Protein|生產(chǎn)廠家|現(xiàn)貨
別名: CINC-2a,  GROb,  Gro2,  MIP-2,  MIP-2a,  Mgsa-b,  Mip2,  Scyb,  Scyb2
表達(dá)方式: A DNA sequence encoding the mature form of mouse CXCL2 ( P10889-1 ) ( Ala 28 - Asn 100 ) was fused with a N-terminal polyhistide-tagged SUMO tag at the N-terminus
種屬: Mouse
表達(dá)宿主: E. coli

CXCL2 / GRO2蛋白質(zhì)控指標(biāo)
純度: > 95 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: Please contact us for more information.
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Met
分子量: The recombinant mouse CXCL2 consisting of 189 amino acids and has a calculated molecular mass of 21.2 kDa. It migrates as a 30 kDa band in SDS-PAGE under reducing conditions
緩沖液: Lyophilized from sterile 0.1% TFA, pH 2.9
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CXCL2 / GRO2蛋白使用指南

儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CXCL2 / GRO2蛋白背景綜述
Mouse C-X-C motif chemokine 2, also known as growth-regulated protein beta, macrophage inflammatory protein 2-alpha, MIP2-alpha, CXCL2 and GRO2, is a secreted protein which belongs to the intercrine alpha (chemokine CxC) family. CXCL2 / MIP2-alpha is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. CXCL2 / MIP2-alpha has been known to regulate immune functions mainly by chemo-attracting neutrophils. It is produced by activated monocytes and neutrophils and expressed at sites of inflammation. CXCL2 / MIP2-alpha is Hematoregulatory chemokine, which suppresses hematopoietic progenitor cell proliferation. CXCL2 / MIP2-alpha can be induced by receptor activator of NF-kappaB ligand, the osteoclast (OC) differentiation factor, through JNK and NF-kappaB signaling pathways in OC precursor cells. CXCL2 in turn enhanced the proliferation of OC precursor cells of bone marrow-derived macrophages (BMMs) through the activation of ERK. Knockdown of CXCL2 inhibited both the proliferation of and the ERK activation in BMMs. During osteoclastogenesis CXCL2 stimulated the adhesion and the migration of BMMs. CXCL2 is a novel therapeutic target for inflammatory bone destructive diseases.
參考文獻(xiàn)
Pelus LM, et al., 2006, Exp Hematol. Aug;34(8):1010-20.
De Plaen,I.G. et al., 2006, Immunology. 118 (2):153-63.
Rubio,N. et al., 2006, Cell Immunol. 239 (1):31-40.
Hohl,T.M. et al., 2008,J Infect Dis. 198 (2):176-85.
Ha,J. et al., 2010, J Immunol. 184 (9):4717-24.

包裝：20ug

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