IL-8(aa 6-77) 蛋白產(chǎn)品信息
產(chǎn)品名稱：重組人 IL-8 (aa 6-77) 蛋白|IL8(aa 6-77) Protein|產(chǎn)品詳情|參數(shù)
IL-8 別名: CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF,
表達(dá)方式: The 72 amino acid residue form (Ser 28- Ser 99) of mature human IL8 (NP_000575.1) was expressed and purified.
種屬: Human
表達(dá)宿主: Human Cells

IL-8(aa 6-77) 蛋白質(zhì)控指標(biāo)
純度: > 95% as determined by SDS-PAGE. SDS-PAGE:
內(nèi)**: < 1.0 EU per 1μg of the protein as determined by the LAL method.
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Ser 28
分子量: The recombinant human cytokine IL8 isoform comprising 72 amino acids predicts a molecular mass of 8.5 kDa, and migrates as an approximately 12kDa protein in SDS-PAGE.due to glycosylation.
緩沖液: Lyophilized from sterile 100mM NaCl, 50mM Tris, pH7.5

IL-8(aa 6-77) 蛋白使用指南
儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage and usage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IL-8(aa 6-77) 蛋白背景綜述
Interleukin-8 (IL8), also known as CXCL8, is a member of the CXC chemokine family of small (8–10 kDa) proteins, a subfamily of chemokines within the cytokine superfamily. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli (IL-1, TNF, LPS, etc). IL8 has the N-terminal tripeptide Glu-Leu-Arg (ELR) motif, which is known to mediate IL8 receptor binding and subsequent signal transduction, such as the TRAF6- NF-κB pathway, and involved in inflammatory and allergic responses. Furthermore, it has been shown that IL8 also plays a vital role in angiogenesis which is important for tumorigenesis, progression and metastasis, and accordingly the expression levels of IL8 correlate with disease progression in several human carcinomas. Multiple N-terminal processed forms for this protein are available, and this purified IL8 (6-77 amino acids) is the most prominent one.

參考文獻(xiàn)
Baqqiolini, M. et al., 1992, FEBS. Lett. 307: 97-101
Koch, A.E. et al., 1992, Science. 258: 1798-1801.
Bar-Eli, M. et al., 1999, Pathobiology. 67: 12-18.
Charalambous, C. et al., 2005, Cancer. Res. 65: 10347-10354.
Manna, S.K. et al., 2005, J. Biol. Chem. 280: 7010-7021.

包裝：50ug

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