FGF21蛋白產(chǎn)品信息
產(chǎn)品名稱：重組小鼠 FGF21 / Fibroblast Growth Factor 21 蛋白|FGF21 Protein|產(chǎn)品詳情|現(xiàn)貨
別名: FGF-21
表達(dá)方式: A DNA sequence encoding the mouse FGF21 ( Q9JJN1 ) ( Met 1 - Ser 210 ) was expressed, with a polyhistidine tag at the C-terminus
種屬: Mouse
表達(dá)宿主: Human Cells

FGF21蛋白質(zhì)控指標(biāo)
純度: > 85 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Ala 29
分子量: The secreted recombinant mouse FGF21 consists of 193 amino acids and has a calculated molecular mass of 21.3 kDa. As a result of glycosylation, the apparent molecular mass of rm FGF21 is approximately 25 kDa in SDS-PAGE under reducing conditions
緩沖液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
FGF21蛋白使用指南
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

FGF21蛋白背景綜述
The fibroblast growth factors ( FGFs ) are a growing family of heparin-binding growth factors that regulate a variety of physiological processes in both developing and ***** organism. FGFs function as key secreted signalling molecules in many developmental events. Mouse fibroblast growth factor 21 ( FGF21 ) is a member of endocrine FGFs subfamily, along with FGF19 and FGF23. It is emerging as a novel regulator with beneficial effects on a variety of metabolic parameters, including glucose and lipid control. FGF21 functions as a metabolic regulator. The FGF21 transcript is abundantly expressed in liver. FGF21 activity depends on membrane protein betaKlotho that physically complexes with various FGF receptors, thus conferring them the ability to bind FGF21 and activate downstream signaling pathways. FGF21, like other FGFs, folds to a beta-trefoil-like core region, with disordered N- and C-termini. FGF21 recently has been proposed as a missing link in the biology of fasting, it shows significant, non-saturable, unidirectional influx across the blood-brain barrier (BBB). FGF21 is a critical metabolic regulator, pivotal for fasting adaptation and directly regulated by PPARalpha in rodents. FGF21 circulates in human plasma and increases by extreme fasting and PPARalpha activation. The wide interindividual variation and the induction of ketogenesis independent of FGF21 levels indicate that the physiological role of FGF21 in humans may differ from that in mice.
參考文獻(xiàn)
Hsuchou, H. et al., 2007, Peptides. 28 (12): 2382-6.
Yamauchi,H. et al., 2006, EMBO Rep. 7 (6): 649-54.
Izumiya,Y. et al., 2008, FEBS Lett 582 (27): 3805-10.
Arner,P. et al., FEBS Lett 2008, 582 (12): 1725-30.
Micanovic,R. et al., 2009, J Cell Physiol. 219 (2): 227-34.

包裝：20ug

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查詢關(guān)鍵詞：重組小鼠 FGF21 / Fibroblast Growth Factor 21 蛋白，F(xiàn)GF21 Protein，產(chǎn)品詳情，現(xiàn)貨，原料藥，大包裝定制，現(xiàn)貨促銷，醫(yī)藥中間體，科學(xué)儀器，實(shí)驗(yàn)室耗材，生化試劑，創(chuàng)賽中國,細(xì)胞因子
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