IGFBP6 / IBP-6蛋白產(chǎn)品信息
產(chǎn)品名稱：重組人 IGFBP6 / IBP-6 蛋白|Insulin-like Growth Factor-binding Protein 6|現(xiàn)貨|參數(shù)
別名: IBP6
表達(dá)方式: A DNA sequence encoding the human IGFBP6 ( P24592 ) ( Met 1 - Gly 240 ) was fused with a polyhistidine tag at the C-terminus
種屬: Human
表達(dá)宿主: Human Cells

IGFBP6 / IBP-6蛋白質(zhì)控指標(biāo)
純度: > 96 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Arg 28
分子量: The recombinant human IGFBP6 consists of 224 amino acids and has a predicted molecular mass of 23.9 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhIGFBP6 is approximately 36 kDa due to glycosylation
緩沖液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IGFBP6 / IBP-6蛋白使用指南
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IGFBP6 / IBP-6蛋白背景綜述
Insulin-like growth factor-binding protein 6, also known as IGF-binding protein 6, IGFBP-6 and IBP-6, is a secreted protein which contains one IGFBP N-terminal domain and one thyroglobulin type-1 domain. The insulin-like growth factor (IGF) axis is a complex system composed of two mitogenic ligands, IGF-I and IGF-II, two receptors, IGF-IR and IGF-IIR, and six binding proteins, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, IGFBP6. IGF-binding proteins ( IGFBPs ) prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.The IGFBPs exert their actions through their regulation of IGF bioavailability for IGF receptors. Increased IGFBP6 / IBP6 expression in oral tumors could be regarded as a potential predictive marker of tumor sensitivity and could be used for prognostic purposes, since a significant correlation could be observed between increased induction of apoptotic cell death and elevated levels of IGFBP6 / IBP6 in these tumors.
參考文獻(xiàn)
Saito,T. et al., 2003, Zoolog Sci. 20 (4):441-7.
Kamangar,B.B. et al., 2006, Endocrinology. 147 (5):2399-410.
Shynlova,O. et al., 2007, Biol Reprod. 76 (4):571-8.
Zhang,L. et al., 2007, Dig Dis Sci. 52 (1):248-53.
Cacalano,N.A. et al., 2008, Apoptosis. 13 (12):1439-49.

包裝：5ug  20ug

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查詢關(guān)鍵詞：重組人 IGFBP6 / IBP-6 蛋白，Insulin-like Growth Factor-binding Protein 6，現(xiàn)貨，參數(shù)，原料藥，大包裝定制，現(xiàn)貨促銷，醫(yī)藥中間體，科學(xué)儀器，實驗室耗材，生化試劑，創(chuàng)賽中國,細(xì)胞因子
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