IGFBP6 / IBP-6蛋白產(chǎn)品信息

別名: 
IGFBP-6
表達(dá)方式: 重組小鼠 IGFBP6 / IBP-6 蛋白|IGFBP6 / IBP-6 Protein|產(chǎn)品詳情|現(xiàn)貨
A DNA sequence encoding the mouse IGFBP6 ( NP_032370.2 ) ( Met 1 -Gly 238 ) was expressed, with a polyhistidine tag at the C-terminus
種屬: Mouse
表達(dá)宿主: Human Cells
IGFBP6 / IBP-6蛋白質(zhì)控指標(biāo)
產(chǎn)品名稱：
純度: > 92 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測(cè)N端: Gln 20
分子量: The recombinant mouse IGFBP6 consists of 224 amino acids and has a predicted molecular mass of 24 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmIGFBP6 is approximately 30 kDa due to glycosylation
緩沖液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IGFBP6 / IBP-6蛋白使用指南
儲(chǔ)存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
IGFBP6 / IBP-6蛋白背景綜述
Mouse insulin-like growth factor-binding protein 6, also known as IGF-binding protein 6, IGFBP-6 and IBP-6, is a secreted protein which contains one IGFBP N-terminal domain and one thyroglobulin type-1 domain. The insulin-like growth factor (IGF) axis is a complex system composed of two mitogenic ligands, IGF-I and IGF-II, two receptors, IGF-IR and IGF-IIR, and six binding proteins, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, IGFBP6. IGF-binding proteins ( IGFBPs ) prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.The IGFBPs exert their actions through their regulation of IGF bioavailability for IGF receptors. Increased IGFBP6 / IBP6 expression in oral tumors could be regarded as a potential predictive marker of tumor sensitivity and could be used for prognostic purposes, since a significant correlation could be observed between increased induction of apoptotic cell death and elevated levels of IGFBP6 / IBP6 in these tumors.
參考文獻(xiàn)
Saito,T. et al., 2003, Zoolog Sci. 20 (4):441-7.
Kamangar,B.B. et al., 2006, Endocrinology. 147 (5):2399-410.
Shynlova,O. et al., 2007, Biol Reprod. 76 (4):571-8.
Zhang,L. et al., 2007, Dig Dis Sci. 52 (1):248-53.
Cacalano,N.A. et al., 2008, Apoptosis. 13 (12):1439-49.

包裝：5ug  20ug

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