IGF2 / IGF-II蛋白產(chǎn)品信息
產(chǎn)品名稱：重組人 IGF2 / IGFII / Somatomedin-A 蛋白|IGF2 / IGF-II Protein|產(chǎn)品詳情|價格
別名: PP1446,  C11orf43,  FLJ22066,  FLJ44734,  IGF-II,  PP9974
表達方式: A DNA sequence encoding the mature form of human IGF2 ( P01344-1 ) ( Ala 25 - Glu 91 ) was fused with the polyhistidine-tagged NusA tag at the N-terminus
種屬: Human
表達宿主: E. coli

IGF2 / IGF-II蛋白質(zhì)控指標(biāo)
純度: > 90 % as determined by SDS-PAGE SDS-PAGE
內(nèi)**: Please contact us for more information.
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預(yù)測N端: Met
分子量: The recombinant human IGF2/NusA chimera consisting of 580 amino acids and has a calculated molecular mass of 64.6 kDa. It migrates as a 70 kDa band in SDS-PAGE under reducing conditions
緩沖液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
IGF2 / IGF-II蛋白使用指南
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IGF2 / IGF-II蛋白背景綜述
Insulin-like growth factor II, also known as IGF-II, Somatomedin-A and IGF2, is a secreted protein which belongs to the insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ) and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. The IGFs possess growth-promoting activity. They are potent mitogens for cultured cells. IGF-I expression is regulated by growth hormone and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF2 / IGF-II is perhaps the most intricately regulated of all growth factors characterized to date. IGF2 / IGF-II activity is controlled through differential expression of receptors and IGF-binding proteins (IGFBPs) that determine protein availability. IGF2 / IGF-II is influenced by placental lactogen and may play a role in fetal development. Genetic variations in IGF2 are associated with body mass index (BMI). BMI is a statistical measurement which compares a person's weight and height.
參考文獻
Dull T.J., et al., 1984, Nature 310:777-781.
Bell G.I., et al., 1984, Nature 310:775-777.
Ager,E.I. et al., 2008, BMC Dev Biol  8 :17.
Chao,W. et al., 2008, Cytokine Growth Factor Rev. 19 (2):111-20.
Martin-Trujillo,A. et al., 2010, Ann Rheum Dis. 69 (6):1239-42.

包裝：5ug  50ug

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