IGFBP4 蛋白產(chǎn)品信息
產(chǎn)品名稱：重組人 IGFBP4 蛋白|Insulin-Like Growth Factor Binding Protein 4 |技術資料|價格
IGFBP4 別名: BP-4, HT29-IGFBP, IBP4, IGFBP-4, IGFBP4
表達方式: A DNA sequence encoding the human IGFBP4 (NP_001543.2) precursor (Met 1- Glu 258) with a C-terminal polyhistidine tag was expressed.
種屬: Human
表達宿主: Human Cells

IGFBP4 蛋白質(zhì)控指標
純度: > 95%, as determined by SDS-PAGE SDS-PAGE
內(nèi)**: < 1.0 EU per 1μg of the protein as determined by the LAL method.
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Asp 22
分子量: The secreted recombinant human IGFBP4 comprises 248 amino acids with a predicted molecular mass of 27.4 kDa. As a result of glycosylation, it migrates as an approximately 32 kDa band in SDS-PAGE under reducing conditions.
緩沖液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
IGFBP4蛋白使用指南
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
IGFBP4 蛋白背景綜述
Insulin-like growth factor-binding proteins (IGFBPs) control bioavailability, activity, and distribution of insulin-like growth factor (IGF) through high-affinity IGFBP/IGF complexes. Six high-affinity IGF-binding proteins (IGFBP-1 to -6) have been identified, and IGFBP4, the smallest IGFBP expressed by a wide range of cell types, exists in both non-glycosylated and N-glycosylated forms in all biological fluids. Structurally consisting of an IGFBP domain and a thyroglobulin type-I domain, IGFBP4 binds IGF-I and IGF-II with similar affinities as a transport protein and modulates their biological effects. Increasing evidences indicate that IGFBP4 inhibits IGF-induced cellular growth both in vitro and in vivo. As an important member of the IGF system, IGFBP4 is involved in a wide range of biological processes including reproductive physiology, bone formation, renal pathophysiology and carcinomas.
參考文獻
Durai, R. et al., 2006, Int. J. Oncol. 28: 1317-1325.
Sitar, T. et al., 2006, Proc. Natl. Acad. Sci. U.S.A. 103: 13028-13033.
Zhou, R. et al., 2003, J. Endocrinol. 178: 177-193.
Zhou, J. et al., 2003, Biol. Reprod. 69: 22-29.

包裝：5ug   20ug

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