NOV / CCN3蛋白產(chǎn)品信息
產(chǎn)品名稱：重組人 NOV / CCN3 蛋白|Protein NOV Homolog ( NOV / CCN3 ) Protein|技術(shù)資料|現(xiàn)貨
別名: NOV,  CCN3,   IGFBP9
表達方式: A DNA sequence encoding the full length of human NOV ( NP_002505.1 ) ( Met 1 - Met 357 ) was expressed, fused with a polyhistidine tag at the C-terminus
種屬: Human
表達宿主: Insect cells

NOV / CCN3蛋白質(zhì)控指標
純度: > 94 % as determined by SDS-PAGE SDS-PAGE
Bio-activity :Measured by the ability of the immobilized protein to support the adhesion of Balb/3T3 mouse embryonic fibroblast cells.
When cells are added to CCN3 coated plates ( 10μg/mL, 100 μL/well ), >50% cells will adhere specifically after 60 minutes at  37 ℃
內(nèi)**: < 1.0 EU per μg of the protein as determined by the LAL method
穩(wěn)定性: Samples are stable for up to twelve months from date of receipt at -70℃
預測N端: Thr 32
分子量: The secreted recombinant human NOV consists of 337 amino acids and predicts a molecular mass of 37 kDa. It migrates as an approximately 47 KDa band in SDS-PAGE under reducing conditions
緩沖液: Lyophilized from sterile 50mM Tris, 100mM NaCl,  0.5mM PMSF, 10mM Imidazole, 10% Glycerol ,  pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
NOV / CCN3蛋白使用指南
儲存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage.  Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
NOV / CCN3蛋白背景綜述
Protein NOV homolog, also known as Nephroblastoma-overexpressed gene protein homolog, NOV, and CCN3, is secreted protein which belongs to the CCN family. CCN3 expression was observed in a broad variety of tissues from the early stage of development. It contains one CTCK (C-terminal cystine knot-like) domain, one IGFBP N-terminal domain, one TSP type-1 domain, and one VWFC domain. CCN3, a founding member of the CCN family of growth regulators, was linked with hematology in 2003 when it was detected in human serum. CCN3 acts through the core stem cell signalling pathways including Notch and Bone Morphogenic Protein, connecting CCN3 with the modulation of self-renewal and maturation of a number of cell lineages including hematopoietic, osteogenic and chondrogenic. Altered CCN3 expression is associated with numerous solid tumors including glioblastoma, melanoma, adrenocortical tumours, prostate cancer and bone malignancies including osteosarcoma. CCN3 may affect the extracellular environment of the niche for hematopoietic stem cells. CCN3 has emerged as a key player in stem cell regulation, hematopoiesis and a crucial component within the bone marrow microenvironment.
參考文獻
Lombet, A. et al., 2003,Cell Commun Signal. 1 (1): 1.
Katsube, K. et al., 2009, J Cell Commun Signal. 3 (2): 135-45.
McCallum,L. et al., 2009,  Blood Rev. 23 (2): 79-85.
McCallum, LJ. et al., 2009, Cell Commun Signal. 3 (2):115-24.

包裝：5ug  50ug

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