產(chǎn)品名稱:Purified 小鼠抗人 p16 with Control 抗體；Purified Mouse Anti-Human p16 with Control
中文名稱:Purified 小鼠抗人p16 with Control 抗體
英文名稱:Purified Mouse Anti-Human p16 with Control
Purified Mouse Anti-Human p16 with Control 產(chǎn)品介紹：
Material Number: 551154
Alternate Name: p16-INK4, p16-INK4a, ARF, MTS1, CDKN2, CDK4l
Reactivity: QC Testing: Human
Component: 51-1325GR
Description: Purified Mouse Anti-Human p16
Size: 50 μg (3 ea)
Concentration: 0.25 mg/ml
Clone Name: G175-405
Immunogen: Human p16 Recombinant Protein
Isotype: Mouse IgG1
Target MW: 16 kDa
Storage Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Component: 51-16516N
Description: HeLa Control Lysate
Size: 50 μg (1 ea)
Concentration: 1.0 mg/ml
Storage Buffer: SDS-PAGE buffer (62mM Tris pH 6.8, 2% SDS, 0.9% b-mercaptoethanol,
0.003% bromophenol blue, 5% glycerol)
Purified Mouse Anti-Human p16 with Control Description：
Cyclins and cyclin-dependent kinases (cdks) form active complexes that regulate key events during the progression of the cell cycle and are
evolutionarily highly conserved. The p16 protein has been identified as a specific inhibitor of cdk4 because it blocks cdk4 substrate
phosphorylation. p16 inhibits cdk4 dependent phosphorylation of the tumor suppressor retinoblastoma protein (Rb) and Rb related proteins,
p107 and p130. The biochemical properties of p16 suggest that it may be a tumor suppressor gene product. Recently a gene cloned from the
short arm of human chromosome 9, Multiple Tumor Suppressor 1 (MTS1) has been identified as the gene for p16. The gene, now also known
as the CDKN2 gene, has been found to be mutated in a very high percentage of tumors, including 75% of melanoma cell lines.
Purified Mouse Anti-Human p16 with Control Preparation and Storage：
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Store both the Purified Mouse Anti-Human p16 antibody (component 51-1325GR) and the HeLa control lysate (component
51-16516N) undiluted at -20°C.
