產(chǎn)品名稱:FITC 小鼠抗人 CD209 抗體；FITC Mouse Anti-Human CD209

中文名稱:FITC 小鼠抗人 CD209 抗體

英文名稱:FITC Mouse Anti-Human CD209

FITC Mouse Anti-Human CD209 產(chǎn)品介紹：

Material Number: 551264
Alternate Name: DC-SIGN
Size: 100 tests
Vol. per Test: 20 μl
Clone: DCN46
Immunogen: Human Monocyte Derived DC Cells
Isotype: Mouse IgG2b, κ
Reactivity: QC Testing: Human
Storage Buffer: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.


FITC Mouse Anti-Human CD209 Description：

The DCN46 antibody reacts with dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN or CD209), a type-II membrane protein of 
approximately 44 kDa with a mannose-binding C-type lectin domain. It is highly expressed on dendritic cells in mucosal tissues. Its sequence 
is identical to the HIV-1 envelope gp120-binding C-type lectin, and reports suggest that DC-SIGN binds to HIV-1 gp120 and effectively 
transmits infectious HIV-1 to resting T lymphocytes expressing CD4 and chemokine receptors. The C-type lectin domain of DC-SIGN is also 
capable of binding other pathogenic viruses, bacteria, and parasites. Reports also suggest that DC-SIGN enables the highly efficient migration 
of dendritic cells from blood into the tissues. It can interact with ICAM-2, which has a similar sequence as ICAM-3, and is abundantly expressed on vascular and lymphoid endothelium. Thus, DC-SIGN mediates dendritic cells rolling and transendothelial migration, and its 
interaction with ICAM-2 is essential to specific migratory functions of dendritic cells.

FITC Mouse Anti-Human CD209 Preparation and Storage：

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with FITC under optimum conditions, and unreacted FITC was removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.