產(chǎn)品名稱(chēng):PE-Cy?7 大鼠抗小鼠 CD11b 抗體；PE-Cy?7 Rat Anti-Mouse CD11b

中文名稱(chēng):PE-Cy?7 大鼠抗小鼠 CD11b 抗體

英文名稱(chēng):PE-Cy?7 Rat Anti-Mouse CD11b

PE-Cy?7 Rat Anti-Mouse CD11b 產(chǎn)品介紹：

Material Number: 552850
Alternate Name: Integrin α[M] chain, Mac-1 α chain, CR3 α chain
Size: 0.1 mg
Concentration: 0.2 mg/ml
Clone: M1/70
Immunogen: Mouse splenic Cells
Isotype: Rat (DA) IgG2b, κ
QC Testing: Mouse
Reported: Human
Reactivity:
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.


PE-Cy?7 Rat Anti-Mouse CD11b Description：

The M1/70 antibody reacts with the 170-kDa α[M] chain of Mac-1 (CD11b/CD18, α[M]β[2] integrin), also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1 (CD54). Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 cells. Mac-1 expression is rapidly up-regulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface. M1/70 antibody reportedly blocks cell adherence and C3bi binding, but it does not block cell-mediated lysis. Cross-reaction of mAb M1/70 with CD11b on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported.

PE-Cy?7 Rat Anti-Mouse CD11b Preparation and Storage：

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with PE-Cy7 under optimum conditions, and unconjugated antibody and free PE-Cy7 were removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.