產(chǎn)品名稱:FITC 大鼠抗小鼠 CD45RB 抗體；FITC Rat Anti-Mouse CD45RB

中文名稱:FITC 大鼠抗小鼠 CD45RB 抗體

英文名稱:FITC Rat Anti-Mouse CD45RB

FITC Rat Anti-Mouse CD45RB 產(chǎn)品介紹：

Material Number: 553099
Size: 0.1 mg
Concentration: 0.5 mg/ml
Clone: 16A
Immunogen: Cloned Mouse TH2 cell lines
Isotype: Rat IgG2a, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.



FITC Rat Anti-Mouse CD45RB Description：

The 16A antibody reacts with an exon B-dependent epitope of CD45 lycoprotein, which is found at high density on peripheral B cells, T 
cytotoxic/suppressor cells, subset of T helper cells, and most thymocytes and at low density on macrophages and dendritic cells.The level of 
CD45RB expression appears to decrease as T lymphocytes progress from naive to memory cells. In addition, subpopulations of CD4+ T cells 
which express high and low levels of D45RB have different ytokine secretion profiles and mediate distinct immunological functions. CD25+ 
D4+ regulatory T (Treg) lymphocytes which control intestinal inflammation and autoimmunity express low levels of D45RB. CD45 is a 
member of the Protein Tyrosine Phosphatase (PTP) family: Its intracellular (COOH-terminal) region contains two PTP catalytic domains, and 
the extracellular region is highly variable due to alternative splicing of exons (designated A, B, and C, respectively), plus differing levels of 
glycosylation. The CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific. The CD45 isoforms play 
complex roles in T-cell and B-cell antigen receptor signal transduction.

FITC Rat Anti-Mouse CD45RB Preparation and Storage：

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with FITC under optimum conditions, and unreacted FITC was removed.
Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.