產(chǎn)品名稱(chēng):PE 小鼠抗小鼠 NK-1.1 抗體；PE Mouse Anti-Mouse NK-1.1

中文名稱(chēng):PE 小鼠抗小鼠 NK-1.1 抗體

英文名稱(chēng):PE Mouse Anti-Mouse NK-1.1

PE Mouse Anti-Mouse NK-1.1 產(chǎn)品介紹：

Material Number: 553165
Alternate Name: NKR-P1B and NKR-P1C
Size: 0.2 mg
Concentration: 0.2 mg/ml
Clone: PK136
Immunogen: Mouse NK-1+ Spleen and Bone Marrow Cells
Isotype: Mouse (C3H x BALB/c) IgG2a, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.



PE Mouse Anti-Mouse NK-1.1 Description：

In the mouse, at least three members of the Klrb (Killer cell lectin-like receptor, subfamily b; formerly NKR-P1) gene family have been 
identified (Klrb1a/NKR-P1A, Klrb1b/NKR-P1B, and Klrb1c/NKR-P1C); but in the human gene family, a single homologue has been 
designated KLRB1, NKR-P1A, or CD161. The KLRB1/NKR-P1 family of proteins are type-II-transmembrane C-type lectin receptors. 
KLRB1C/NKR-P1C activates NK-cell cytotoxicity, while KLRB1B/NKR-P1B functions as an inhibitory receptor. KLRB1B/NKR-P1B 
protein has intracellular Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM), while KLRB1C/NKR-P1C lacks ITIM and activates via 
association with Fc Receptor γ chain. Strikingly, KLRB1B/NKR-P1B and KLRB1C/NKR-P1C share 96% amino acid sequence identity in 
their extracellular C-type lectin domains. The PK136 antibody reacts with the NK-1.1 surface antigen encoded by the Klrb1c/NKR-P1C gene 
expressed on natural killer (NK) cells in selected strains of mice (eg, C57BL, FVB/N, NZB, but not A, AKR, BALB/c, CBA/J, C3H, C57BR, 
C58, DBA/1, DBA/2, NOD, SJL, 129) and the antigen encoded by the Klrb1b/NKR-P1B gene expressed only on Swiss NIH and SJL mice, but 
not on C57BL/6. Expression of KLRB1C/NKR-P1C protein is correlated with the ability to lyse tumor cells in vitro and to mediate rejection 
of bone marrow allografts. The NK-1.1 marker is useful in defining NK cells; however, the antigen is also expressed on a rare, specialized 
population of T lymphocytes (NK-T cells) and some cultured monocytes. Plate-bound PK136 mAb, in combination with low concentrations of 
IL-2, induces proliferation of a subset of NK cells.

PE Mouse Anti-Mouse NK-1.1 Preparation and Storage：

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.