產(chǎn)品名稱:PE 大鼠抗小鼠 CD24 抗體；PE Rat Anti-Mouse CD24

中文名稱:PE 大鼠抗小鼠 CD24 抗體

英文名稱:PE Rat Anti-Mouse CD24

PE Rat Anti-Mouse CD24 產(chǎn)品介紹：

Material Number: 553262
Alternate Name: Heat Stable Antigen
Size: 0.1 mg
Concentration: 0.2 mg/ml
Clone: M1/69
Immunogen: C57BL/10 Mouse Splenic T Lymphocytes
Isotype: Rat (DA) IgG2b, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.



PE Rat Anti-Mouse CD24 Description：

The M1/69 antibody reacts with CD24 (Heat-Stable Antigen, HSA or HsAg), a variably glycosylated GPI-anchored membrane protein found 
on erythrocytes, granulocytes, monocytes, lymphocytes, and neurons. Hematopoietic stem cells of the embryonic yolk sac and fetal liver 
express CD24.5 Levels of expression of CD24 vary during differentiation of the T and B cell lineages. In the bone marrow, hematopoietic 
progenitors acquire CD24 expression upon commitment to the B-lymphocyte lineage. Immature B cells in the bone marrow and spleen of ***** 
mice peripheral B lymphocytes express intermediate levels of CD24. The level of CD24 expression has been reported to rise upon activation 
of splenic B cells with LPS, but not with CD154 (CD40 Ligand). The majority of thymocytes express high levels of CD24, while most mature 
thymic and peripheral T lymphocytes do not express CD24. In contrast, TCR-bearing thymocytes which emigrate to the spleen are CD24+. 
Dendritic cells of the thymus, spleen, liver, and epidermal Langerhans cells have also been reported to express CD24. CD24 is not expressed 
by NK cells, as determined by staining with J11d mAb (Cat. No. 553146). CD24 is involved in the costimulation of CD4+ T cells by B cells, it 
is a "co-inducer" of in vitro thymocyte maturation, and it is a ligand of CD62P (P-selectin). While the monoclonal antibodies 30-F1, M1/69, 
and J11d all react with CD24, they show subtle differences in the level of staining of different lymphocyte populations. When possible, 
investigators should continue to use the same monoclonal antibody as used in previous studies. 

PE Rat Anti-Mouse CD24 Preparation and Storage：

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.