產(chǎn)品名稱:Purified 大鼠抗小鼠 CD11b 抗體；Purified Rat Anti-Mouse CD11b

中文名稱:Purified 大鼠抗小鼠 CD11b 抗體

英文名稱:Purified Rat Anti-Mouse CD11b

Purified Rat Anti-Mouse CD11b 產(chǎn)品介紹：

Material Number: 553308
Alternate Name: Integrin α[M] chain, Mac-1 α chain, CR3
Size: 0.5 mg
Concentration: 0.5 mg/ml
Clone: M1/70
Immunogen: C57BL/10 splenic T cells and concanavalin A-activated C57BL/10 splenocytes
Isotype: Rat (DA) IgG2b, κ
Reactivity:QC Testing: Mouse
Reported: Human
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide


Purified Rat Anti-Mouse CD11b Description：

The M1/70 antibody reacts with the 170 kDa α[M] chain of Mac-1 (CD11b/CD18, α[M]β2 integrin), also known as complement receptor 3 
(CR3), which mediates adhesion to C3bi and ICAM-1 (CD54). Mac-1 is expressed at varying levels on granulocytes, macrophages, 
myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 cells. Mac-1 expression is rapidly up-regulated on neutrophils after 
activation, in the same time period that CD62L (L-selectin) is shed from the cell surface. M1/70 antibody reportedly blocks cell adherence and 
C3bi binding, but it does not block cell-mediated lysis. Cross-reaction of mAb M1/70 with CD11b on human monocytes, polymorphonuclear 
leukocytes, and NK cells has been reported. 

Purified Rat Anti-Mouse CD11b Preparation and Storage：

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Store undiluted at 4° C.