產品名稱:FITC 大鼠抗小鼠CD117 抗體；FITC Rat Anti-Mouse CD117
中文名稱:FITC 大鼠抗小鼠 CD117 抗體
英文名稱:FITC Rat Anti-Mouse CD117
FITC Rat Anti-Mouse CD117 產品介紹：
Material Number: 553354
Alternate Name: c-Kit
Size: 0.5 mg
Concentration: 0.5 mg/ml
Clone: 2B8
Immunogen: Mouse Bone Marrow Mast Cells
Isotype: Rat (WI) IgG2b, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium
azide.
FITC Rat Anti-Mouse CD117 Description：
The 2B8 antibody reacts with CD117 (c-Kit), a transmembrane tyrosine-kinase receptor which is encoded by the Kit gene (formerly dominant
white spotting, W). The c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor) encoded by the Kit1 gene
(formerly steel, SI), is a co-mitogen for hematopoietic stem cells, myeloerythroid progenitors and a mast-cell differentiation factor. The KitW
and Kit1SI mutant alleles have similar pleiotropic effects on the development of melanocytes, germ cells, and the hematopoietic system. In the
***** bone marrow, CD117 is expressed on hematopoietic progenitor cells, including CD90 (Thy-1) low, TER-119-, CD45R/B220-, CD11b
(Mac-1)-, Ly-6G (Gr-1)-, CD4-, CD8-, and Sca-1 (Ly-6A/E)+ multipotent hemotopoietic stem cells, progenitors committed to myeliod and/or
erythroid lineages, and precursors of B and T lymphocytes. This widespread expression of CD117 in hematopoietic precursors is consistent
with the participation of c-Kit and its ligand in the regulation of several hematopoietic lineages. Intrathymic expression of c-Kit and c-Kit
ligand suggest that CD117 is also involved in the regulation of some events during the development of T lymphocytes. CD117 is also
expressed by mast cells and by dendritic cells found in the periarteriolar lymphocytoc sheaths (T-cell areas) of splenic white pulp. The mAb
2B8 reportedly does not block the action of c-Kit. This clone 2B8 had been reported that there was cross-reactivity with rat.
FITC Rat Anti-Mouse CD117 Preparation and Storage：
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with FITC under optimum conditions, and unreacted FITC was removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
