產(chǎn)品名稱:PE 大鼠抗小鼠 CD117 抗體；PE Rat Anti-Mouse CD117

中文名稱:PE 大鼠抗小鼠 CD117 抗體

英文名稱:PE Rat Anti-Mouse CD117

PE Rat Anti-Mouse CD117 產(chǎn)品介紹：

Material Number: 553355
Alternate Name: c-Kit
Size: 0.2 mg
Concentration: 0.2 mg/ml
Clone: 2B8
Immunogen: Mouse Bone Marrow Mast Cells
Isotype: Rat (WI) IgG2b, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide



PE Rat Anti-Mouse CD117 Description：

The 2B8 antibody reacts with CD117 (c-Kit), a transmembrane tyrosine-kinase receptor which is encoded by the Kit gene (formerly dominant 
white spotting, W). The c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor) encoded by the Kit1 gene 
(formerly steel, SI), is a co-mitogen for hematopoietic stem cells, myeloerythroid progenitors and a mast-cell differentiation factor. The KitW 
and Kit1SI mutant alleles have similar pleiotropic effects on the development of melanocytes, germ cells, and the hematopoietic system. In the 
***** bone marrow, CD117 is expressed on hematopoietic progenitor cells, including CD90 (Thy-1) low, TER-119-, CD45R/B220-, CD11b 
(Mac-1)-, Ly-6G (Gr-1)-, CD4-, CD8-, and Sca-1 (Ly-6A/E)+ multipotent hemotopoietic stem cells, progenitors committed to myeliod and/or 
erythroid lineages, and precursors of B and T lymphocytes. This widespread expression of CD117 in hematopoietic precursors is consistent 
with the participation of c-Kit and its ligand in the regulation of several hematopoietic lineages. Intrathymic expression of c-Kit and c-Kit 
ligand suggest that CD117 is also involved in the regulation of some events during the development of T lymphocytes. CD117 is also 
expressed by mast cells and by dendritic cells found in the periarteriolar lymphocytoc sheaths (T-cell areas) of splenic white pulp. The mAb 
2B8 reportedly does not block the action of c-Kit. This clone 2B8 had been reported that there was cross-reactivity with rat

PE Rat Anti-Mouse CD117 Preparation and Storage：

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.