產(chǎn)品名稱(chēng):FITC 大鼠抗小鼠 CD86 抗體；FITC Rat Anti-Mouse CD86
中文名稱(chēng):FITC 大鼠抗小鼠 CD86 抗體
英文名稱(chēng):FITC Rat Anti-Mouse CD86
FITC Rat Anti-Mouse CD86 產(chǎn)品介紹：
Material Number: 553691
Alternate Name: B7-2
Size: 0.5 mg
Concentration: 0.5 mg/ml
Clone: GL1
Immunogen: Mouse (CBA/Ca) LPS-activated splenic B Cells
Isotype: Rat (LOU) IgG2a, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.
FITC Rat Anti-Mouse CD86 Description：
The GL1 antibody has been reported to react with the B7-2 (CD86) costimulatory molecule expressed on a broad spectrum of leukocytes,
including B lymphocytes, T lymphocytes, thioglycollate-induced peritoneal macrophages, dendritic cells and astrocytes. CD86 is expressed at
low levels by freshly explanted peripheral B and T cells, and its expression is substantially increased by a variety of T cell- and B cell-specific
stimuli with a peak expression after 18-42 hours of culture. In contrast to most naive CD4+ T cells, memory CD4+ T cells express B7-2, both
at the mRNA and protein level. CD86, a ligand for CD28 and CD152 (CTLA-4), is one of the accessory molecules that plays an important role
in T cell-B cell costimulatory interactions. It has been shown to be involved in immunoglobulin class-switching and triggering of mouse NK
cell-mediated cytotoxicity. CD80 (B7-1) is an alternate ligand for CD28 and CD152 (CTLA-4). GL1 antibody reportedly blocks MLR and
stimulation of T cells by natural antigen-presenting cells. In addition, a mixture of anti-B7-1 and anti B7-2 (GL1) mAbs reportedly inhibits the
in vitro interaction of CTLA-4 with its ligand and the in vivo priming of cytotoxic T lymphocytes.
FITC Rat Anti-Mouse CD86 Preparation and Storage：
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with FITC under optimum conditions, and unreacted FITC was removed.
Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.
