產(chǎn)品名稱:PE 大鼠抗小鼠 CD86 抗體；PE Rat Anti-Mouse CD86

中文名稱:PE 大鼠抗小鼠 CD86 抗體

英文名稱:PE Rat Anti-Mouse CD86

PE Rat Anti-Mouse CD86 產(chǎn)品介紹：

Material Number: 553692
Alternate Name: B7-2
Size: 0.2 mg
Concentration: 0.2 mg/ml
Clone: GL1
Immunogen: Mouse (CBA/Ca) LPS-activated splenic B Cells
Isotype: Rat (LOU) IgG2a, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide

PE Rat Anti-Mouse CD86 Description：

The GL1 antibody has been reported to react with the B7-2 (CD86) costimulatory molecule expressed on a broad spectrum of leukocytes,
including B lymphocytes, T lymphocytes, thioglycollate-induced peritoneal macrophages, dendritic cells and astrocytes. CD86 is expressed at
low levels by freshly explanted peripheral B and T cells, and its expression is substantially increased by a variety of T cell- and B cell-specific
stimuli with a peak expression after 18-42 hours of culture. In contrast to most naive CD4+ T cells, memory CD4+ T cells express B7-2, both
at the mRNA and protein level. CD86, a ligand for CD28 and CD152 (CTLA-4), is one of the accessory molecules that plays an important role
in T cell-B cell costimulatory interactions. It has been shown to be involved in immunoglobulin class-switching and triggering of mouse NK
cell-mediated cytotoxicity. CD80 (B7-1) is an alternate ligand for CD28 and CD152 (CTLA-4). GL1 antibody reportedly blocks MLR and
stimulation of T cells by natural antigen-presenting cells. In addition, a mixture of anti-B7-1 and anti B7-2 (GL1) mAbs reportedly inhibits the
in vitro interaction of CTLA-4 with its ligand and the in vivo priming of cytotoxic T lymphocytes.

PE Rat Anti-Mouse CD86 Preparation and Storage：

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed by gel
filtration chromatography.
Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.