產品名稱:FITC 倉鼠抗小鼠 CD80 抗體；FITC Hamster Anti-Mouse CD80
中文名稱:FITC 倉鼠抗小鼠 CD80 抗體
英文名稱:FITC Hamster Anti-Mouse CD80
FITC Hamster Anti-Mouse CD80 產品介紹：
Material Number: 553768
Alternate Name: B7-1
Size: 0.5 mg
Concentration: 0.5 mg/ml
Clone: 16-10A1
Immunogen: Mouse CD80 (B7) Transfected Cell Line
Isotype: Armenian Hamster IgG2, κ
Reactivity:QC Testing: Mouse
Reported: Dog
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.
FITC Hamster Anti-Mouse CD80 Description：
The 16-10A1 antibody reacts with CD80 (B7-1). This member of the Ig superfamily, along with CD86 (B7-2), participates in T-cell
co-stimulation via interactions with CD28 and CD152 (CTLA-4). CD80 has been reported to be constitutively expressed on dendritic cells,
monocytes, and peritoneal macrophages; and it is inducible on B cells by various means, including activation by LPS, IL-4, and the
cross-linking of surface Ig. Expression of CD80 has been reported to be greatly enhanced on splenic B cells following activation by LPS, with
peak expression occurring between 48 and 72 hours. It has been reported that the activation of purified B cells with LPS can induce CD80
expression in as few as 18 hours. The 16-10A1 antibody has been reported to block binding of CTLA-4 Ig to CD80 and to block T-cell
activation by Con A-elicited peritoneal exudate cells and CD80-transfected cell lines. However, 16-10A1 antibody alone is not able to block
T-cell activation by antigen-presenting cells. CD86 (B7-2) is an alternate ligand for CD28 and CD152 (CTLA-4). Preliminary reports indicate
that the 16-10A1 mAb may block the binding of rat anti-CD80 mAb clone 1G10 (Cat. No. 553368). In addition, it has been reported that the
16-10A1 antibody may cross-react with an activation antigen expressed on IFN-γ-activated alveolar macrophages of the dog.
FITC Hamster Anti-Mouse CD80 Preparation and Storage：
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with FITC under optimum conditions, and unreacted FITC was removed.
Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.
