產(chǎn)品名稱:Biotin 小鼠抗小鼠 CD45.1 抗體；Biotin Mouse Anti-Mouse CD45.1
中文名稱:Biotin 小鼠抗小鼠 CD45.1 抗體
英文名稱:Biotin Mouse Anti-Mouse CD45.1
Biotin Mouse Anti-Mouse CD45.1 產(chǎn)品介紹：
Material Number: 553774
Size: 0.5 mg
Concentration: 0.5 mg/ml
Clone: A20
Immunogen: SJL mouse thymocytes and splenocytes
Isotype: Mouse (A.SW) IgG2a, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.
Biotin Mouse Anti-Mouse CD45.1 Description：
The A20 antibody reacts with CD45 (Leukocyte Common Antigen) on all leukocytes of mouse strains expressing the CD45.1 alloantigen (eg,
RIII, SJL/J, STS/A, DA). This alloantigen was originally named Ly-5.2, and this was the designation at the time that the antibody was
characterized. The designation was later changed from Ly-5.2 to Ly-5.1 to conform with the convention that the .2 alloantigen designations be
assigned to the C57BL/6 strain. mAb A20 has been reported not to react with leukocytes of most other mouse strains, which express the
CD45.2 alloantigen. CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: Its intracellular (COOH-terminal) region contains
two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated A, B, and
C, respectively), plus differing levels of glycosylation. The CD45 isoforms detected in the mouse are cell type-, maturation-, and activation
state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction. The A20 antibody has been
reported to inhibit some responses of B cells, from mice expressing the CD45.1 alloantigen, to antigens and LPS.
Biotin Mouse Anti-Mouse CD45.1 Preparation and Storage：
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.
