產(chǎn)品名稱:Biotin 大鼠抗小鼠 CD19 抗體；Biotin Rat Anti-Mouse CD19
中文名稱:Biotin 大鼠抗小鼠 CD19 抗體
英文名稱:Biotin Rat Anti-Mouse CD19
Biotin Rat Anti-Mouse CD19 產(chǎn)品介紹：
Material Number: 553784
Size: 0.5 mg
Concentration: 0.5 mg/ml
Clone: 1D3
Immunogen: Mouse CD19 Transfected Cell Line
Isotype: Rat (LEW) IgG2a, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.
Biotin Rat Anti-Mouse CD19 Description：
The 1D3 antibody reacts with CD19, a B lymphocyte-lineage differentiation antigen. CD19, a 95kDa transmembrance glycoprotein, is a
member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell through the mature
B-cell stages. Terminally differentiated plasma cells do not express CD19. On the surface of mature B cells, the CD19 molecule associates
with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to promote cellular
activation. Studies with CD19-deficient mice have suggested that the level of CD19 expression affects the generation and maturation of B cells
in the bone marrow and periphery. B-1 lineage B cells, also known as CD5+ B cells, are drastically reduced or absent in CD19-deficient mice.
Increased levels of CD19 expression correlate with increased frequencies of peritonal and splenic B-1 cells and reduced numbers of
conventional B lymphocytes in the periphery. CD19 participates in B-lymphocyte development, B-cell activation, maturation of memory B
cells and regulation of tolerance. CD19 has also been detected on peritoneal mast cells, co-localized with CD21/CD35, and it is proposed to
play a role in complement-mediated mast-cell activation.
Biotin Rat Anti-Mouse CD19 Preparation and Storage：
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.
