產(chǎn)品名稱:Purified NA/LE 大鼠抗小鼠 CD40 抗體；Purified NA/LE Rat Anti-Mouse CD40
中文名稱:Purified NA/LE 大鼠抗小鼠 CD40 抗體
英文名稱:Purified NA/LE Rat Anti-Mouse CD40
Purified NA/LE Rat Anti-Mouse CD40 產(chǎn)品介紹：
Material Number: 553787
Size: 0.5 mg
Concentration: 1.0 mg/ml
Clone: 3/23
Immunogen: Mouse CD40 Recombinant Protein
Isotype: Rat (LOU) IgG2a, κ
Reactivity: QC Testing: Mouse
Storage Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative,
0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of
protein as determined by the LAL assay.
Purified NA/LE Rat Anti-Mouse CD40 Description：
The 3/23 clone reacts with CD40, a 40-50 kDa glycoprotein expressed on B lymphocytes and other antigen-presenting cells. CD40 has been
reported to be transiently expressed on activated CD4+ and CD8+ T cells and in some mouse strains, the 3/23 mAb has been reported to react
with 5-10% of T lymphocytes in ***** mouse, but not neonatal, spleen. CD40 plays a key role in B-cell growth and differentiation where
interactions of CD40 with its ligand, CD154, are involved in the initiation, effector, and memory stages of cell-mediated immune responses.
In addition, CD40 has been reported to be involved with the triggering of NK cells and NK-T cells. Ligation of CD40 with the 3/23 antibody
has been reported to induce splenic B cells to express the costimulatory molecule CD86 (B7-2). In addition, although the 3/23 antibody by
itself is a weak B-cell mitogen, it has been reported to synergize markedly with mitogenic anti-IgM, anti-IgD mAb or IL-4 to promote B-cell
proliferation.
Purified NA/LE Rat Anti-Mouse CD40 Preparation and Storage：
Store undiluted at 4°C.
This preparation contains no preservatives, thus it should be handled under aseptic conditions.
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
