產(chǎn)品名稱:PE 大鼠抗小鼠 CD40 抗體；PE Rat Anti-Mouse CD40

中文名稱:PE 大鼠抗小鼠 CD40 抗體

英文名稱:PE Rat Anti-Mouse CD40

PE Rat Anti-Mouse CD40 產(chǎn)品介紹：

Material Number: 553791
Size: 0.2 mg
Concentration: 0.2 mg/ml
Clone: 3/23
Immunogen: Mouse CD40 Recombinant Protein
Isotype: Rat (LOU) IgG2a, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.

PE Rat Anti-Mouse CD40 Description：

The 3/23 clone reacts with CD40, a 40-50 kDa glycoprotein expressed on B lymphocytes and other antigen-presenting cells. CD40 has been
reported to be transiently expressed on activated CD4+ and CD8+ T cells and in some mouse strains, the 3/23 mAb has been reported to react
with 5-10% of T lymphocytes in ***** mouse, but not neonatal, spleen. CD40 plays a key role in B-cell growth and differentiation where
interactions of CD40 with its ligand, CD154, are involved in the initiation, effector, and memory stages of cell-mediated immune responses. In
addition, CD40 has been reported to be involved with the triggering of NK cells and NK-T cells. Ligation of CD40 with the 3/23 antibody has
been reported to induce splenic B cells to express the costimulatory molecule CD86 (B7-2). In addition, although the 3/23 antibody by itself is
a weak B-cell mitogen, it has been reported to synergize markedly with mitogenic anti-IgM, anti-IgD mAb or IL-4 to promote B-cell
proliferation.

PE Rat Anti-Mouse CD40 Preparation and Storage：

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.