產(chǎn)品名稱:Purified 小鼠抗人 JNK1/JNK2 抗體；Purified Mouse Anti-Human JNK1/JNK2

中文名稱:Purified 小鼠抗人 JNK1/JNK2 抗體

英文名稱:Purified Mouse Anti-Human JNK1/JNK2

Purified Mouse Anti-Human JNK1/JNK2 產(chǎn)品介紹：

Material Number: 554285
Size: 0.1 mg
Concentration: 0.5 mg/ml
Clone: G151-666
Immunogen: Human JNK1 Fusion Protein
Isotype: Mouse IgG2a
Reactivity: QC Testing: Human
Target MW: 46 kDa (JNK1), 54 kDa (JNK2)
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide

Purified Mouse Anti-Human JNK1/JNK2 Description：

C-Jun NH2-terminal kinase (JNK) binds to the c-Jun terminal transactivation domain and phosphorylates it on Ser-63 and Ser-73.
Phosphorylation enhances the transcriptional activity of c-Jun. The Ser-Pro-acidic sequence targeted by JNK kinase activity establishes it as a
prolinedirected kinase related to the MAP kinases and cyclin/dependent kinases. JNK may act as a tumor promoter in response to
UV-irradiation since its activity is potently stimulated by radiation. This has relevance to observations that c-Jun transcriptional activity is
upregulated by UV irradiation. In addition to UV irradiation, JNK is also activated by some other forms of cellular stress, including heatshock.
Both the JNK1 (46 kDa) and JNK2 (54 kDa) isozymes appear equally capable of binding to the c-Jun terminal transactivation domain
following induction by UV irradiation or heatshock. G151-666 recognizes both the JNK1 and JNK2 isozymes of JNK1. A bacterially
expressed fusion protein of human JNK1 was used as immunogen.

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Store undiluted at 4°C.