產(chǎn)品名稱:FITC 小鼠抗大鼠 CD8a 抗體；FITC Mouse Anti-Rat CD8a

中文名稱:FITC 小鼠抗大鼠 CD8a 抗體

英文名稱:FITC Mouse Anti-Rat CD8a

FITC Mouse Anti-Rat CD8a 產(chǎn)品介紹：

Material Number: 554856
Size: 0.5 mg
Concentration: 0.5 mg/ml
Clone: OX-8
Immunogen: High-molecular-weight rat thymocyte glycoproteins
Isotype: Mouse (BALB/c) IgG1, κ
Reactivity: QC Testing: Rat
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.

FITC Mouse Anti-Rat CD8a Description：

The OX-8 antibody reacts with the hinge-like membrane-proximal domain of the 32 kDa α chain of the CD8 differentiation antigen. A
truncated CD8 α' isoform has not been detected in the rat. The CD8 α and β chains (CD8a and CD8b, respectively) form a heterodimer on the
surface of most thymocytes and a subpopulation of mature T lymphocytes (i.e., MHC class I-restricted T cells, including most T
suppressor/cytotoxic cells). Intestinal intrapithelial lymphocytes, many CD8+ T cells of athymic rats, many activated CD4+ T cells, and most
NK cells express CD8a without CD8b. It has been suggested that the expression of the CD8a/CD8b heterodimer is restricted to
thymus-derived T lymphocytes. OX-8 antibody does not react with resting CD4+ T helper cells. CD8 is an antigen coreceptor on the T-cell
surface which interacts with MHC class I molecules on antigen-presenting cells. It participates in T-cell activation through its association with
the T-cell receptor complex and protein tyrosine kinase Ick. Macrophages have also been reported to express CD8 α and β chains, which are
involved in signal transduction. Soluble OX-8 mAb partially blocks in vitro MLR and CTL activity.

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with FITC under optimum conditions, and unreacted FITC was removed.
Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.