產(chǎn)品名稱:PE 小鼠抗大鼠 CD31 抗體；PE Mouse Anti-Rat CD31

中文名稱:PE 小鼠抗大鼠 CD31 抗體

英文名稱:PE Mouse Anti-Rat CD31

PE Mouse Anti-Rat CD31 產(chǎn)品介紹：

Material Number: 555027
Alternate Name: PECAM-1
Size: 0.1 mg
Concentration: 0.2 mg/ml
Clone: TLD-3A12
Immunogen: Lewis Rat Microglia
Isotype: Mouse (BALB/c) IgG1, κ
QC Testing: Rat
Tested in Development: Pig
Reactivity:
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.

PE Mouse Anti-Rat CD31 Description：

The TLD-3A12 antibody reacts with CD31, also known as PECAM-1 (platelet endothelial cell adhesion molecule). CD31 is a ~130 kDa
integral membrane glycoprotein, a member of the immunoglobulin super family, that mediates homophilic and heterophilic cell-cell adhesion.
CD31 is expressed on endothelial cells, platelets, and subsets of leukocytes. In the human and mouse, multiple alternatively spliced isoforms
have been identified, and this alternative splicing may be involved in the regulation of ligand specificity. CD31-mediated endothelial cell-cell
interactions are involved in angiogenesis in the mouse and rat. In addition, PECAM-1 has been demonstrated to play an important role in
extravasation of leukocytes in vivo, but in vivo treatment with TLD-3A12 mAb had no discernable effect upon the inflammatory infiltrate in
experimental allergic encephalomyelitis. The TLD-3A12 mAb partially blocks the proliferation response of antigen-specific CD4+ T cells to
antigen-presenting cells and relevant antigen. This mouse anti-rat CD31 antibody cross-reacts with pig endothelial cells and platelets, as
determined by immunohistochemical staining of acetone-fixed frozen sections and immunofluorescent staining with flow cytometric analysis,
respectively. A suspension of Lewis rat microglial cells were used as the source of the immunogen.

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed by gel
filtration chromatography.
Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.