PE Mouse anti-Human CD39
產(chǎn)品名稱: PE Mouse anti-Human CD39
產(chǎn)品型號: BD-555464
產(chǎn)品展商: BD Pharmingen
產(chǎn)品文檔: 無相關文檔
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PE Mouse anti-Human CD39
的詳細介紹
產(chǎn)品名稱:PE 小鼠抗人 抗體;PE Mouse anti-Human CD39
中文名稱:PE 小鼠抗人 抗體
英文名稱:PE Mouse anti-Human CD39
PE Mouse anti-Human CD39 產(chǎn)品介紹:
Material Number: 555464
Alternate Name: ENTPD1, NTPDase 1
Size: 100 tests
Vol. per Test: 20 μl
Clone: TU66
Isotype: Mouse IgG2b, κ
Reactivity: QC Testing: Human
Storage Buffer: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
PE Mouse anti-Human CD39 Description:
The TU66 monoclonal antibody reacts with human CD39 also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) an
ectoenzyme that degrades ATP to AMP. It is a member of the family of ectonucleoside triphosphate dihydrolases (E-NTPDases) known to be
involved in regulation of extracellular nucleotide catabolism, controlling the extracellular nucleoside triphosphate pool (NTP). CD39 is
expressed on a subset of T cells, B cells and dendritic cells with weak staining of monocytes and granulocytes. Recently, CD39 has been
found to be expressed primarly by immune-suppressive Foxp3(+) regulatory T (Treg) cells in both human and mice. In humans, CD39 is
restricted to a subset of Foxp3(+) regulatory effector/memory-like T cells. In mice, the enzyme is present on most if not all CD4(+)CD25(+)
cells and CD39 expression is driven by Foxp3. It is thought that CD39 allows Treg cells to enter inflamed areas where high levels of ATP are
present.
PE Mouse anti-Human CD39 Preparation and Storage:
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.