產品名稱:PE Annexin V

PE Annexin V 產品介紹：

Material Number: 556421
Size: 200 tests
Vol. per Test: 5 μl
Storage Buffer: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

PE Annexin V Description：

Apoptosis is a normal physiologic process which occurs during embryonic development as well as in maintenence of tissue homeostasis. The
apoptotic program is characterized by certain morphologic features, including loss of plasma membrane asymmetry and attachment,
condensation of the cytoplasm and nucleus, and internucleosomal cleavage of DNA. Loss of plasma membrane is one of the earliest features.
In apoptotic cells, the membrane phospholipid phosphatidylserine (PS) is translocated from the inner to the outer leaflet of the plasma
membrane, thereby exposing PS to the external cellular environment. Annexin V is a 35-36 kDa Ca2+ dependent phospholipid-binding
protein that has a high affinity for PS, and binds to cells with exposed PS. Annexin V may be conjugated to fluorochromes including
phycoerythrin (PE). This format retains its high affinity for PS and thus serves as a sensitive probe for flow cytometric analysis of cells that are
undergoing apoptosis. Since externalization of PS occurs in the earlier stages of apoptosis, PE Annexin V staining can identify apoptosis at an
earlier stage than assays based on nuclear changes such as DNA fragmentation.

Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.