產(chǎn)品名稱:Purified Mouse Anti-p21
Purified Mouse Anti-p21 產(chǎn)品介紹：
Material Number: 556430
Size: 0.1 mg
Concentration: 0.5 mg/ml
Clone: SX118
Immunogen: Purified Human p21 Recombinant Fusion Protein
Isotype: Mouse IgG1, κ
Human, Mouse, Rat
Reactivity:QC Testing: Human, Mouse
Target Molecular Weight: 21 kDa
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide
Purified Mouse Anti-p21 Description：
Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes.
Cyclins (regulatory subunits) to form complexes that regulate the progression of the cell cycle. The activity of these complexes is modulated
by activating and inhibitory phosphorylation events, as well as by interactions with small regulatory proteins including, p16, p21, p27 and
others. These proteins, referred to as inhibitors of Cdk activity (CDkIs) bind to cyclins, cdks or their complexes. p21, also known as senescent
cell-derived inhibitor 1 (Sdi1), wild-type p53-activated fragment 1 (Waf1), Cdk-interacting protein 1 (Cip1), and p53-regulated inhibitor of
Cdks (Pic1) inhibits cyclin D-cdk4, cyclin E-cdk3, cyclin A-cdk2, and cyclin A-cdk1. p21 can also inhibit cell cycle progression by binding to
PCNA and blocking DNA replication. p21 has also shown to be a component of active cyclin-cdk complexes, suggesting that p21-containing
complexes may shift between active and inactive states through changes in p21 content. Active, p21-containing complexes appear to contain
one p21 molecule, whereas inactive complexes contain multiple p21 molecules. The expression of p21 can be induced in response to number
of signals, including transcriptional upregulation by the tumor suppressor protein, p53. Human p21 has a calculated molecular weight of 18
kDa and runs at 21 kDa in SDS-PAGE.
Purified Mouse Anti-p21 Preparation and Storage：
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Store undiluted at 4° C.
Purified Mouse Anti-p21 Suggested Companion Products：
Catalog Number Name Size Clone
611449 HeLa Cell Lysate 500 μg (none)
554002 HRP Goat Anti-Mouse Igs 1.0 ml (none)
