FITC Rat Anti-Mouse CD19
產(chǎn)品名稱: FITC Rat Anti-Mouse CD19
產(chǎn)品型號: BD-557398
產(chǎn)品展商: BD Pharmingen
產(chǎn)品文檔: 無相關文檔
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FITC Rat Anti-Mouse CD19
的詳細介紹
產(chǎn)品名稱:FITC 大鼠抗小鼠 CD19 抗體;FITC Rat Anti-Mouse CD19
中文名稱:FITC 大鼠抗小鼠 CD19 抗體
英文名稱:FITC Rat Anti-Mouse CD19
FITC Rat Anti-Mouse CD19 產(chǎn)品介紹:
Material Number: 557398
Size: 0.1 mg
Concentration: 0.5 mg/ml
Clone: 1D3
Immunogen: Mouse CD19 Transfected Cell Line
Isotype: Rat (LEW) IgG2a, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.
FITC Rat Anti-Mouse CD19 Description:
The 1D3 antibody reacts with CD19, a B lymphocyte-lineage differentiation antigen. CD19, a 95kDa transmembrance glycoprotein, is a
member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell through the mature
B-cell stages. Terminally differentiated plasma cells do not express CD19. On the surface of mature B cells, the CD19 molecule associates
with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to promote cellular
activation. Studies with CD19-deficient mice have suggested that the level of CD19 expression affects the generation and maturation of B cells
in the bone marrow and periphery. B-1 lineage B cells, also known as CD5+ B cells, are drastically reduced or absent in CD19-deficient mice.
Increased levels of CD19 expression correlate with increased frequencies of peritonal and splenic B-1 cells and reduced numbers of
conventional B lymphocytes in the periphery. CD19 participates in B-lymphocyte development, B-cell activation, maturation of memory B
cells and regulation of tolerance. CD19 has also been detected on peritoneal mast cells, co-localized with CD21/CD35, and it is proposed to
play a role in complement-mediated mast-cell activation.
FITC Rat Anti-Mouse CD19 Preparation and Storage:
Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.
The antibody was conjugated with FITC under optimum conditions, and unreacted FITC was removed.
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.