產(chǎn)品名稱:Purified 小鼠抗小鼠 CD244.2 抗體；Purified Mouse Anti-Mouse CD244.2
中文名稱:Purified 小鼠抗小鼠 CD244.2 抗體
英文名稱:Purified Mouse Anti-Mouse CD244.2
Purified Mouse Anti-Mouse CD244.2 產(chǎn)品介紹：
Material Number: 557451
Alternate Name: 2B4 B6 Alloantigen
Size: 0.1 mg
Concentration: 0.5 mg/ml
Clone: 2B4
Immunogen: rIL-2-propagated NK1.1+ cells from C57BL/6 mice
Isotype: Mouse (129) IgG2b, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.
Purified Mouse Anti-Mouse CD244.2 Description：
CD244 is a member of the CD2 subset of the immunoglobulin superfamily (CD2 IgSF). It is expressed on all natural killer (NK) cells,
IL-2-activated NK (LAK) cells, committed progenitors of NK cells, and a subset of T lymphocytes which mediate non-MHC-restricted
cytoxicity, including dendritic epidermal T cells. The 2B4 antibody reacts with CD244.2, the 2B4 alloantigen which is expressed on C57BL/6
and C58/J mice, but not in most strains tested (A/J, AKR, BALB/c, CBA/J, CBA/N, C3H/He, C57BR, DBA/1, DBA/2, NZB, SJL/J, 129). At
least two isoforms of CD244.2 protein, products of alternative splicing of hnRNA, are expressed on IL-2-activated C57BL/6 NK cells. They
differ only in their cytoplasmic domains; with 2B4L (150-aa cytoplasmic tail) having inhibitory activity and 2B4S (93-aa tail) being
stimulatory. The extracellular domain of CD244 is a ligand for another CD2 IgSF member, CD48. 2B4 antibody activates lytic and secretory
functions of IL-2-cultured NK cells and CD244.2+ T cells.
Purified Mouse Anti-Mouse CD244.2 Preparation and Storage：
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Store undiluted at 4° C.
