產(chǎn)品名稱:Biotin 大鼠抗小鼠 CD45RA 抗體；Biotin Rat Anti-Mouse CD45RA

中文名稱:Biotin 大鼠抗小鼠 CD45RA 抗體

英文名稱:Biotin Rat Anti-Mouse CD45RA

Biotin Rat Anti-Mouse CD45RA 產(chǎn)品介紹：

Material Number: 557460
Size: 0.1 mg
Concentration: 0.5 mg/ml
Clone: 14.8
Immunogen: Radiation-induced NZC mouse B lymphoma WEHI-279
Isotype: Rat IgG2b, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.



Biotin Rat Anti-Mouse CD45RA Description：

The 14.8 clone has been reported to react with an exon A-dependent epitope of the CD45 protein, which is found at high density on B cells 
and at low density on peripheral T cytotoxic/suppressor cells and a very small subset of thymocytes. Nearly all B-lineage cells, including 
B-cell precursors in fetal liver and ***** bone marrow and Ig-secreting cells, but not hematopoietic stem cells or myeloid progenitors, have 
been reported to be detectable by mAb 14.8. CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: Its intracellular 
(COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of 
exons 4, 5, and 6 (designated A, B, and C, respectively), plus, differing levels of glycosylation. The CD45 isoforms detected in the mouse are 
cell type-, maturation-, and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal 
transduction. mAb 14.8 has been reported to enhance the proliferative effect of PHA on purified spleen T cells, possibly by replacing a signal 
normally delivered by accessory cells, to enhance isotype switching during in vitro B-cell responses, and to inhibit antigen-induced p21 [ras] 
activation. 

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.