產(chǎn)品名稱:PE 小鼠抗人 CD278 抗體；PE Mouse Anti-Human CD278
中文名稱:PE 小鼠抗人 CD278 抗體
英文名稱:PE Mouse Anti-Human CD278
PE Mouse Anti-Human CD278 產(chǎn)品介紹：
Material Number: 557802
Alternate Name: ICOS
Size: 100 tests
Vol. per Test: 20 μl
Clone: DX29
Immunogen: Activated human T cells
Isotype: Mouse IgG1, κ
Reactivity: QC Testing: Human
Storage Buffer: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
PE Mouse Anti-Human CD278 Description：
Monoclonal antibody DX29 reacts with inducible costimulatory (ICOS) molecule. ICOS is a homodimeric membrane glycoprotein, member of
the CD28 family, of approximately 50 - 60 kDa, highly expressed on activated T cells. It is the receptor for B7 related protein 1 (B7RP-1) and
also, like CD28, ICOS is costimulatory signal for T cell activation, proliferation and cytokine production. It is not expressed on resting or
activated B cells, monocytes, NK cells, granulocytes, dendritic cells or platelets. Unlike the constitutively expressed CD28, ICOS expression
is de novo. Reports describe similarities of CD28 and ICOS in T cell activation, however, it has been suggested that ICOS may play an
important role in IL-10 production. In presence IL-10, purified recombinant human ICOS significantly increased in vitro B cell growth
stimulated by pokeweed mitogen (PWM) and enhanced production of IgG.
PE Mouse Anti-Human CD278 Preparation and Storage：
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
Store undiluted at 4° C and protected from prolonged exposure to light. Do not freeze.
