FITC Mouse Anti-Human CD279
產(chǎn)品名稱: FITC Mouse Anti-Human CD279
產(chǎn)品型號: BD-557860
產(chǎn)品展商: BD Pharmingen
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
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FITC Mouse Anti-Human CD279
的詳細(xì)介紹
產(chǎn)品名稱:FITC 小鼠抗人 CD279 抗體；FITC Mouse Anti-Human CD279
中文名稱:FITC 小鼠抗人 CD279 抗體
英文名稱:FITC Mouse Anti-Human CD279
FITC Mouse Anti-Human CD279 產(chǎn)品介紹：
Material Number: 557860
Alternate Name: PD-1
Size: 0.1 mg
Concentration: 0.5 mg/ml
Clone: MIH4
Isotype: Mouse IgG1, κ
Reactivity: QC Testing: Human
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.
FITC Mouse Anti-Human CD279 Description：
Reacts with the program death 1 (PD-1) receptor CD279, a member of the Ig superfamily. CD279 is an immunoregulatory receptor expressed
on activated T cells, B cells and myeloid cells. Mice deficient in CD279 show a breakdown of peripheral tolerance and manifest multiple
autoimmune symptoms. It contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region. PD-L1 and PD-L2
are ligands of CD279 and are members of the B7 gene family. Interaction of CD279:PD-Ligands results in inhibition of T cell proliferation
and cytokine secretion. Reports suggest that the B7/CTLA-4 pathway functions primarily to attenuate, limit, and/or terminate na?ve T-cell
activation in secondary lymphoid organs. The PD-ligand:CD279 pathway, on the other hand, may primarily attenuate, limit, and/or terminate
T-, B-, and myeloid cell activation/effector function at sites of inflammation in the periphery
FITC Mouse Anti-Human CD279 Preparation and Storage：
The antibody was conjugated with FITC under optimum conditions, and unreacted FITC was removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography
