PE Mouse Anti-Akt (pT308)
產(chǎn)品名稱: PE Mouse Anti-Akt (pT308)
產(chǎn)品型號: BD-558275
產(chǎn)品展商: BD Pharmingen
產(chǎn)品文檔: 無相關(guān)文檔
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PE Mouse Anti-Akt (pT308)
的詳細(xì)介紹
產(chǎn)品名稱:PE Mouse Anti-Akt (pT308)
PE Mouse Anti-Akt (pT308) 產(chǎn)品介紹：
Material Number: 558275
Size: 50 tests
Vol. per Test: 20 μl
Clone: J1-223.371
Immunogen: Phosphorylated Human Akt1 Peptide
Isotype: Mouse IgG1, κ
Reactivity: QC Testing: Mouse
Tested in Development: Human
Storage Buffer: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
PE Mouse Anti-Akt (pT308) Description：
Akt [also known as PKB (Protein kinase B) or RAC-PK (Related to the A and C kinases)] is a family of serine/threonine kinases that contains
a pleckstrin homology (PH) domain. PH domains play important roles in signal transduction. There are three known isoforms of Akt in
mammalian cells [Akt1 (α), Akt2 (β) and Akt3 (γ)]; they are thought to be regulated similarly. Akt is activated by insulin and growth factors
by a mechanism involving phosphoinositide 3-OH kinase. Phosphoinositide 3-OH kinase products bind to the PH domain, resulting in
translocation of Akt to the plasma membrane and activation of Akt to phospho-Akt by upstream kinases. Akt is phosphorylated within the
activation loop at threonine 308 (T308) and the C-terminus at serine 473. Phospho-Akt promotes cell survival by inhibiting apoptosis.
Specifically, phospho-Akt1 has been shown to phosphorylate Bad, a member of the Bcl-2 family that promotes cell death. This
phosphorylation results in the inactivation of the proapoptotic function of Bad. The Akt molecule is thus considered to link extracellular
survival signals (growth factors) with the apoptotic machinery (Bad). Akt is also a key mediator of the metabolic effects of insulin.
Additionally, Akt has been referred to as an oncogene because it has increased activity in a number of tumors.
PE Mouse Anti-Akt (pT308) Preparation and Storage：
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
PE Mouse Anti-Akt (pT308) Suggested Companion Products：
Catalog Number Name Size Clone
557870 Fix Buffer I 250 ml (none)
558050 Perm Buffer III 125 ml (none)
