產(chǎn)品名稱:APC 倉鼠抗小鼠 CD49b 抗體；APC Hamster Anti-Mouse CD49b
中文名稱:APC 倉鼠抗小鼠 CD49b 抗體
英文名稱:APC Hamster Anti-Mouse CD49b
APC Hamster Anti-Mouse CD49b 產(chǎn)品介紹：
Material Number: 558295
Alternate Name: Integrin α2 chain
Size: 0.1 mg
Concentration: 0.2 mg/ml
Clone: HMα2
Immunogen: Mouse colon carcinoma cell line Colon26
Isotype: Armenian Hamster IgG1, κ
Reactivity: QC Testing: Mouse
Storage Buffer: Aqueous buffered solution containing ≤0.09% sodium azide.
APC Hamster Anti-Mouse CD49b Description：
The HMα2 antibody reacts with integrin α2 chain (CD49b), the 150-kDa transmembrane glycoprotein that non-covalently associates with the
integrin β1 subunit (CD29) to form the integrin α2β1 complex known as VLA-2. VLA-2, a receptor for collagen and laminin, is expressed on
some splenic CD4+ T lymphocytes and NK-T cells, intestinal intraepithelial and lamina propria lymphocytes, splenic NK cells, epithelial cells,
and platelets; but it is not on thymocytes or Peyer’s-patch or lymphnode lymphocytes. The expression of VLA-2 is upregulated on
lymphocytes in response to mitogens. The HMα2 antibody has been reported to partially block the interaction of T-cell blasts, but not NK
cells, with collagen. Purified HMα2 mAb blocks the staining of splenic NK cells by the anti-CD49b/Pan-NK Cells mAb DX5 (Cat. No.
553858, for the PE conjugate). Therefore, mAb HMα2 may be used like the DX5 mAb for identification of NK cells.
APC Hamster Anti-Mouse CD49b Preparation and Storage：
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
The antibody was conjugated to APC under optimum conditions, and unconjugated antibody and free APC were removed.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
