人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF
產(chǎn)品名稱: 人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF
產(chǎn)品型號(hào): C02-130-13-100ug
產(chǎn)品展商: peprotech
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF系列產(chǎn)品主要適用于試驗(yàn)室或生化科研相關(guān)試驗(yàn)，CANSPEC品質(zhì)提供的人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF性能**，中文名稱為人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF。產(chǎn)品人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF以其優(yōu)良的品質(zhì)滿足您不同科研實(shí)驗(yàn)的多種需求。
人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF
的詳細(xì)介紹
產(chǎn)品名稱：人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF
產(chǎn)品規(guī)格：
| C02-130-13-100ug | 人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF | 100ug | ￥11,900 |
| C02-130-13-1mg | 人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF | 1mg | ￥54,600 |
| C02-130-13-20ug | 人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF | 20ug | ￥1,960 |
| C02-130-13-500ug | 人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF | 500ug | ￥32,760 |
| C02-130-13-5ug | 人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF | 5ug | ￥680 |
單 位：瓶
關(guān) 鍵 字：人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF
CANSPEC品質(zhì)提供的人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF性能**，英文名稱人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF，簡稱為人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF，中文名稱為 人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF。
產(chǎn)品人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF以其優(yōu)良的品質(zhì)滿足您不同實(shí)驗(yàn)的多種需求。并保證每批人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF的質(zhì)量和 人代謝綜合征色素上皮細(xì)胞衍生因子|Human PEDF品質(zhì)優(yōu)良。
Synonyms : | Pigment epithelium-derived factor, SerpinF1, EPC-1 |
Description : | PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity (1) should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature related neurodegenerative diseases such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers. Recombinant PEDF is a 44.5 kDa non-glycosylated protein containing 400 amino acid residues. (1) Notari, I. et al. J Biol Chem., Vol. 281, 38022-38037. |
Catalog #: | 130-13 |
Source : | E.coli |
Stability : | The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted PEDF is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles. |
Purity : | Greater than 90% by SDS-PAGE gel and HPLC analyses. |
Endotoxin Level : | Endotoxin level is less than 0.1 ng per μg (1EU/μg). |
Biological Activity : | Data Not Available. |
AA Sequence : | MQNPASPPEE GSPDPDSTGA LVEEEDPFFK VPVNKLAAAV SNFGYDLYRV RSSMSPTTNV LLSPLSVATA LSALSLGAEQ RTESIIHRAL YYDLISSPDI HGTYKELLDT VTAPQKNLKS ASRIVFEKKL RIKSSFVAPL EKSYGTRPRV LTGNPRLDLQ EINNWVQAQM KGKLARSTKE IPDEISILLL GVAHFKGQWV TKFDSRKTSL EDFYLDEERT VRVPMMSDPK AVLRYGLDSD LSCKIAQLPL TGSMSIIFFL PLKVTQNLTL IEESLTSEFI HDIDRELKTV QAVLTVPKLK LSYEGEVTKS LQEMKLQSLF DSPDFSKITG KPIKLTQVEH RAGFEWNEDG AGTTPSPGLQ PAHLTFPLDY HLNQPFIFVL RDTDTGALLF IGKILDPRGP |
PubMed Link : | PEDF |
Country of Origin : | USA |
