Synonyms :

CXCL5, ENA-78 (human)

Description :

The murine homolog of ENA-78 is called LIX. LIX is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. LIX is a chemoattractant for neutrophils. The two naturally occurring variants of LIX; LIX 1-78 (GCP-2) and LIX 9-78 (GCP-2), contain 78 and 70 amino acid residues, respectively. LIX contains the four conserved cysteine residues present in CXC chemokines, and also contains the ‘ELR’ motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. Recombinant murine LIX is a 7.6 kDa protein consisting of amino acid residues 9-78 of the full length LIX protein (93 amino acids).

Catalog #:

250-36

Source :

E.coli

Stability :

The lyophilized protein is stable for at least 2 years from date of receipt at -20⁰C. Reconstituted LIX is stable for at least 3 months when stored in working aliquots with a carrier protein at -20⁰C. Avoid repeated freeze/thaw cycles.

Purity :

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin Level :

Endotoxin level is less than 0.1 ng per μg (1EU/μg).

Biological Activity :

Determined by its ability to chemoattract human neutrophils using a concentration range of 10.0-100.0 ng/ml.

AA Sequence :

TELRCVCLTV TPKINPKLIA NLEVIPAGPQ CPTVEVIAKL KNQKEVCLDP EAPVIKKIIQ KILGSDKKKA

PubMed Link :

LIX+AND+mouse

Country of Origin :

USA