描述

CZC-54252是LRRK2高效抑制劑，對(duì)野生型LRRK2和突變型G2019S LRRK2的IC50值分別為1.28和1.85nM。

相關(guān)類別

信號(hào)通路 >> 自噬 >> LRRK2

研究領(lǐng)域 >> 神經(jīng)**

參考文獻(xiàn)

[1]. Ramsden N, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.

[2]. Ramsden N, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.

密度

1.5±0.1 g/cm3

沸點(diǎn)

718.1±70.0 °C at 760 mmHg

分子式

C22H25ClN6O4S

分子量

504.990

閃點(diǎn)

388.1±35.7 °C

質(zhì)量

504.134644

PSA

126.09000

LogP

1.67

蒸汽壓

0.0±2.3 mmHg at 25°C

折射率

1.667

Methanesulfonamide, N-[2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-

czc 54252 hydrochloride

N-{2-[(5-Chloro-2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)amino]phenyl}methanesulfonamide

CZC-54252