描述

GW 441756是特異的高活性原肌球蛋白相關(guān)激酶A（TrkA）抑制劑，IC50為2 nM，對c-Raf1和CDK2幾乎無活性。

相關(guān)類別

信號通路 >> 蛋白酪氨酸激酶 >> Trk Receptor

研究領(lǐng)域 >> 癌癥

參考文獻(xiàn)

[1]. Wood ER, Kuyper L, Petrov KG, Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg Med Chem Lett. 2004 Feb 23;14(4):953-7.

[2]. Eun Joo Jung, Choong Won Kim, Deok Ryong Kim. Cytosolic accumulation of γH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells. Exp Mol Med. 2008 June 30; 40(3): 276-285.

密度

1.3±0.1 g/cm3

沸點(diǎn)

568.0±50.0 °C at 760 mmHg

分子式

C17H13N3O

分子量

275.305

閃點(diǎn)

297.3±30.1 °C

精*確質(zhì)量

275.105865

PSA

46.92000

LogP

2.90

蒸汽壓

0.0±1.6 mmHg at 25°C

折射率

1.708

儲存條件

Store at RT

(3E)-3-[(1-Methyl-1H-indol-3-yl)methylene]-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one

2H-Pyrrolo[3,2-b]pyridin-2-one, 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-, (3Z)-

(3Z)-3-[(1-Methyl-1H-indol-3-yl)methylene]-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one

2H-Pyrrolo[3,2-b]pyridin-2-one, 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-, (3E)-

(3Z)-3-[(1-methyl-1H-indol-3-yl)methylidene]-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one

GW 441756

GW441756